Investigation into conolidine has triggered discovery of the opioid receptor in the body called ACKR3/CXCR7. ACKR3 is apparently essentially the most desired target for conolidine, which also disregards the opposite 4 classical opioid receptors(3). Conolidine has long been located in the tabernaemontana divaricata plant, that is in the Apocynaceae https://judahipdqd.thezenweb.com/alternative-natural-pain-relief-to-replace-traditional-painkillers-an-overview-76134448