Here, we clearly show that conolidine, a purely natural analgesic alkaloid Utilized in conventional Chinese medication, targets ACKR3, thus giving supplemental evidence of the correlation between ACKR3 and ache modulation and opening choice therapeutic avenues to the procedure of Long-term pain. Utilized in traditional Chinese, Ayurvedic, and Thai drugs. https://courtneyo516fxp2.wikinarration.com/user