Epidural clonidine used as an adjunct to community anesthetics has 3 distinct mechanisms of motion. Initial, the stimulation of alpha-two-receptors from the dorsal horn reduces pain transmission. Next, clonidine can cause community vasoconstriction that limits vascular removal of local epidural anesthetics. You may be able to explain to this https://erickqizpe.anchor-blog.com/12357660/everything-about-onolidine