Environmental or self-antigens and homotypic interactions bring about BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals within the microenvironment and growing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic experiments have identified recurrent mutations in genes regulating tumor mobile-microenvironment interac... https://tome085wdm3.bcbloggers.com/profile